Vecovartec Plus 40/12.5 mg - 21 F.C. Tablet

Angiotensin II receptor blocker and thiazide diuretic combination therapy used in the treatment of hypertension.

Administer with or without food.

-Side effects due to Olmesartan: Dizziness, headache, hyperglycemia, hypertriglyceridemia, diarrhea, hematuria, back pain, increased creatine phosphokinase, bronchitis, flu-like symptoms, pharyngitis, rhinitis, sinusitis. -Side effects due to hydrochlorothiazide: Skin photosensitivity, hypokalemia, hypomagnesemia, hypercalcemia, and hyponatremia may occur with hydrochlorothiazide, hyperuricemia, myopia and acute angle-closure glaucoma, hypersensitivity angiitis, hypotension (including orthostatic), alopecia, skin rash, toxic epidermal necrolysis, urticaria, glycosuria, hypomagnesemia, abdominal cramps, anorexia, constipation, diarrhea, gastric irritation, nausea, vomiting, aplastic anemia, thrombocytopenia, anaphylaxis, dizziness, headache, paresthesia, restlessness, vertigo, asthenia, muscle spasm, blurred vision, xanthopsia, acute kidney injury and fever.

-Should not be given to patients suffering from hypersensitivity to Olmesartan or hydrochlorothiazide. -Severe diarrhea with significant weight loss may develop months to years after treatment initiation. -It may cause hyperkalemia. -Hypotension may occur upon initiation in patients who are salt- or volume-depleted. -May be associated with deterioration of renal function and/or increases in serum creatinine, particularly in patients with low renal blood flow. -Use with caution in patients with significant aortic/mitral stenosis. -Avoid use in patients with ascites due to cirrhosis. -Use olmesartan with caution in patients with unstented unilateral/bilateral renal artery stenosis. -Olmesartan has not been shown to be effective for hypertension in children <6 years of age. -In black patients, the BP-lowering effects of ARBs may be less pronounced. -Elderly patients should be adequately hydrated to avoid increasing the risk of drug induced hypotension. -Gout can be precipitated by hydrochlorothiazide. -Hydrochlorothiazide may cause acute transient myopia and acute angle-closure glaucoma. -Hydrochlorothiazide may cause photosensitivity. -Use hydrochlorothiazide with caution in patients with prediabetes or diabetes mellitus. -Use with caution in patients with severe hepatic impairment. -Thiazide diuretics may decrease renal calcium excretion so avoiding use in patients with hypercalcemia. -Use with caution in patients with moderate or high cholesterol concentrations; because, thiazides may increase cholesterol and triglyceride levels. -Hydrochlorothiazide can cause SLE exacerbation or activation. -In case of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.

Store at room temperature.

Interactions due to Olmesartan: -Alfuzosin: May enhance the hypotensive effect of blood pressure lowering agents. -Antipsychotic Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents. -Dapoxetine: May enhance the orthostatic hypotensive effect of Angiotensin II Receptor Blockers. -Duloxetine: blood pressure lowering agents may enhance the hypotensive effect of Duloxetine. -Heparin: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. -Levodopa-containing products: blood pressure lowering agents may enhance the hypotensive effect of Levodopa-Containing Products. -Lithium: Angiotensin II Receptor Blockers may increase the serum concentration of Lithium. -Nicorandil: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. -Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents. -Potassium Salts: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. -Nonsteroidal Anti-Inflammatory Agents: Angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents. -Trimethoprim: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Interactions due to hydrochlorothiazide: -Alcohol (Ethyl): May enhance the orthostatic hypotensive effect of Thiazide diuretics. -Allopurinol: Thiazide diuretics may enhance the potential for allergic or hypersensitivity reactions to Allopurinol. -Antidiabetic Agents: Thiazide diuretics may diminish the therapeutic effect of Antidiabetic Agents. -Multivitamins/Minerals (containing vitamins ADEK, Folate, Iron): Thiazide diuretics may enhance the hypercalcemic effect of Multivitamins/Minerals. -Nonsteroidal Anti-Inflammatory Agents: Thiazide diuretics may enhance the nephrotoxic effect of Nonsteroidal Anti-Inflammatory Agents. -Vitamin D Analogs: Thiazide and Thiazide-Like Diuretics may enhance the hypercalcemic effect of Vitamin D Analogs.

-Drugs that act on the renin-angiotensin system can cause injury to the developing fetus. -It is not known if Olmesartan is excreted in breast milk; thiazide diuretics are excreted in breast milk. Due to the potential for serious adverse reactions in the nursing infant, a decision to whether discontinue nursing or to discontinue the drug, should consider the importance of treatment to the mother. -Ask your physician before taking any medication during pregnancy or lactation.

MARCYRL