Tonoclone Retard 200 mg C.R. - 10 F.C. Tablets

-Focal (partial) onset seizures and generalized onset seizures (monotherapy or adjunctive therapy):Oral: Initial 2 to 3 mg/kg/day (100 to 200 mg/day) or up to 400 mg/day, may gradually increase dose based on seizure control, tolerability, and serum concentrations every ≥5 days in increments of ≤200 mg/day to a usual maintenance dose of ~10 mg/kg/day (800 mg/day to 1.2 g/day). -Neuropathic pain: For use in trigeminal or glossopharyngeal neuralgia. May also be used in critically ill patients with neuropathic pain as a component of multimodal pain control: Oral: Initial: 200 to 400 mg/day, gradually increasing (eg, over several weeks) in increments of 200 mg/day as needed. Usual maintenance dose: 600 to 800 mg/day; maximum dose: 1.2 g/day. -Bipolar disorder, hypomania and mild to moderate mania or episodes with mixed features and bipolar major depression :Acute treatment (monotherapy): Oral: Initial: 100 to 400 mg/day; may increase dose based on response and tolerability in increments of 200 mg/day every 1 to 4 days; usual dose range: 600 mg/day to 1.2 g/day; maximum dose: 1.6 g/day. -Pediatric dosing: Seizure disorder: Dosage must be adjusted according to patient's response and serum concentrations: Oral: Infants and Children <6 years: Immediate-release formulations: Tablets: Initial: 10 to 20 mg/kg/day in divided doses twice or 3 times daily; titrate at weekly intervals until optimal response; maintenance doses administered 3 or 4 times daily; maximum daily dose: 35 mg/kg/day, suspension: Initial: 10 to 20 mg/kg/day in divided doses 4 times daily; titrate at weekly intervals until optimal response; maintenance doses administered 3 or 4 times daily; maximum daily dose: 35 mg/kg/day. Children ≥6 to 12 years: Immediate-release formulations: Tablets: Initial: 100 mg twice daily, titrate by up to 100 mg/day at weekly intervals. Usual maintenance dose range: 400 to 800 mg/day in 3 to 4 divided doses. Maximum daily dose: 1,000 mg/day.