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Tavanic 500 mg - 5 F.C. Tablet (Old Price)
This page may not cover all the information mentioned in the attached pamphlet of the manufacturing company
Medical Description
Antibiotic, belongs to the Fluoroquinolone group used in the treatment of pneumonia, prostatitis, acute bacterial rhinosinusitis, salmonella infection, drug-resistant tuberculosis and Urinary tract infection.
Indication & Usage
-Acute bacterial rhinosinusitis: Oral: 500 mg or 750 mg once daily for 5 to 7 days.
-Salmonella: Gastrointestinal infection: Oral, IV: 500 mg once daily for 3 to 14 days. While in case of bacteremia: Oral, IV: 500 or 750 mg once daily for 14 days.
-Sexually transmitted infections: Cervicitis/urethritis due to Chlamydia trachomatis: Oral: 500 mg once daily for 7 days.
-Drug-resistant tuberculosis: Oral, IV: 750 mg to 1 g once daily in combination with additional appropriate antituberculosis agents.
-Urinary tract infection: Cystitis, acute uncomplicated or acute simple cystitis: Oral: 250 mg once daily for 3 days (females) or 5 days (males). While in case of complicated urinary tract infection (including pyelonephritis): Oral, IV: 750 mg once daily for 5 to 7 days.
-Acute bacterial prostatitis: Oral, IV: 500 mg once daily for 4 to 6 weeks. While in case of chronic bacterial prostatitis: Oral: 500 mg once daily for 4 to 6 weeks.
-Community-acquired pneumonia: Outpatients with comorbidities or inpatients: Oral, IV: 750 mg once daily.
-Diabetic foot infection: Mild to moderate infection: Oral: 500 mg every 24 hours (750 mg every 24 hours if P. aeruginosa is suspected). While in case of moderate to severe infection: IV: 750 mg every 24 hours.
-Prophylaxis or treatment against bite wound infection (animal or human bite): Oral, IV: 750 mg once daily, in combination with an agent appropriate for anaerobes. Duration of therapy is 3 to 5 days for prophylaxis; duration of treatment for established infection is typically 5 to 14 days and varies based on patient-specific factors, including clinical response.
-Shigella GI infection: Oral: 500 or 750 mg once daily for 3 days; the duration should be extended to 5 to 7 days for those with S. dysenteriae type 1 infection or HIV coinfection.
-Pediatric dosing: See dosage and administration section.
Active Ingredients
Levofloxacin
Recommended Doctors
Dosage & Administration
-Tablets may be administered without regard to meals.
-Oral solution should be administered at least 1 hour before or 2 hours after meals.
-Maintain adequate hydration of patient to prevent crystalluria.
-Administer at least 2 hours before or 2 hours after antacids containing magnesium or aluminum, sucralfate, metal cations (eg, iron), multivitamin preparations with zinc.
-Infuse 250 to 500 mg IV solution over 60 minutes; infuse 750 mg IV solution over 90 minutes.
-Pediatric dosing:
-General dosing for the susceptible infections: Infants ≥6 months, children, and adolescents: 6 months to <5 years: Oral, IV: 8 to 10 mg/kg/dose twice daily, while in case of ≥5 years: Oral, IV: 10 mg/kg/dose once daily; maximum dose: 750 mg/day.
-Pneumonia: Infants ≥6 months and Children <5 years: Oral, IV: 8 to 10 mg/kg/dose every 12 hours; maximum daily dose: 750 mg/day. While in case of children ≥5 years and adolescents ≤16 years: Oral, IV: 8 to 10 mg/kg/dose once every 24 hours; maximum daily dose: 750 mg/day.
-Acute bacterial rhinosinusitis: Children and adolescents: Oral, IV: 10 to 20 mg/kg/day divided every 12 to 24 hours for 10 to 14 days; maximum daily dose: 500 mg/day.
-Multidrug-resistant tuberculosis: Use in combination with at least 3 to 4 additional anti- tuberculosis agents: Infants, children, and adolescents: Oral: 15 to 20 mg/kg/dose once daily; usual maximum daily dose: 1,000 mg/day.
-Nongonococcal urethritis: Adolescents: Oral: 500 mg every 24 hours for 7 days.
-Acute bacterial rhinosinusitis: Children and adolescents: Oral, IV: 10 to 20 mg/kg/day divided every 12 to 24 hours for 10 to 14 days; maximum daily dose: 500 mg/day.
Side Effects
-Aortic aneurysm, arthralgia, phototoxicity/photoallergy and tendinopathy/tendon rupture.
-Chest pain, edema, pruritus , skin rash, abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting, vaginitis, candidiasis, injection site reaction, dizziness, headache, insomnia, dyspnea, palpitations, phlebitis, syncope, ventricular arrhythmia, ventricular tachycardia, urticaria, hyperglycemia, hyperkalemia, hypoglycemia, anorexia, Clostridioides difficile colitis, esophagitis, gastritis, gastroenteritis, glossitis, pancreatitis, stomatitis, anemia, granulocytopenia, thrombocytopenia, abnormal dreams, abnormal gait, agitation, anxiety, confusion, depression, drowsiness, hallucination, hypertonia, nightmares, paresthesia, seizure, vertigo, arthralgia, hyperkinetic muscle activity, myalgia, skeletal pain, tremor, acute kidney injury and epistaxis.
Safety Advice
-In pediatric patients, fluoroquinolones are not routinely first-line therapy, but after assessment of risks and benefits, can be considered a reasonable alternative for situations where no safe and effective substitute is available (eg, multidrug resistance).
-In case of intravenous infusion: Too rapid of infusion can lead to hypotension. Avoid administration through an intravenous line with a solution containing multivalent cations (eg, magnesium, calcium).
-Maintain adequate hydration of patient to prevent crystalluria.
-In case of missed dose: Administer as soon as possible if ≥8 hours until next scheduled dose; otherwise, wait until next scheduled dose.
-Should not be given to patients suffering from hypersensitivity to levofloxacin.
-Prolonged use may result in fungal or bacterial superinfection.
-Use with caution in patients with renal impairment; dosage adjustment required.
-Elderly: Adverse effects (eg, hepatotoxicity, tendon rupture, QT changes, aortic dissection) may be increased in the elderly.
-Hemolytic reactions may (rarely) occur with fluoroquinolone use in patients with G6PD deficiency.
-Safety of use in pediatric patients for >14 days of therapy has not been studied; increased incidence of musculoskeletal disorders (eg, arthralgia, tendon rupture) has been observed in children.
-Fluoroquinolones, including levofloxacin, may cause an exacerbation of myasthenia gravis.
-Incase of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.
Storage
Store at room temperature.
Drug Interactions
-Agents with blood glucose lowering Effects: Quinolones may enhance the hypoglycemic effect of agents with blood glucose Lowering Effects.
-Amiodarone: Levofloxacin-Containing Products (Systemic) may enhance the QTc-prolonging effect of Amiodarone.
-Antacids: May decrease the absorption of Quinolones.
-BCG Vaccine: Antibiotics may diminish the therapeutic effect of BCG Vaccine.
-Calcium Salts: May decrease the absorption of Quinolones.
-Corticosteroids (Systemic): May enhance the adverse/toxic effect of Quinolones.
-Domperidone: QT-prolonging Agents may enhance the QTc-prolonging effect of Domperidone.
-Iron Preparations: May decrease the serum concentration of Quinolones.
-Magnesium Salts: May decrease the serum concentration of Quinolones.
-Multivitamins/Minerals (containing vitamins ADEK, Folate, Iron): May decrease the serum concentration of Quinolones.
-Nonsteroidal anti-inflammatory drugs: May enhance the neuroexcitatory and/or seizure-potentiating effect of Quinolones.
-Ondansetron: May enhance the QTc-prolonging effect of QT-prolonging Quinolone Antibiotics.
-Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.
-Sucralfate: May decrease the serum concentration of Quinolones.
-Vitamin K Antagonists (eg, warfarin): Quinolones may enhance the anticoagulant effect of Vitamin K Antagonists.
-Zinc Salts: May decrease the serum concentration of Quinolones.
Pregnancy & Lactation
-Levofloxacin crosses the placenta and can be detected in the amniotic fluid, based on available data. Antibiotics other than levofloxacin are recommended for the treatment of uncomplicated urinary tract infections and pyelonephritis during pregnancy.
-Levofloxacin is present in breast milk, levofloxacin may be considered for use in breastfeeding patients requiring antibiotics for inhalational anthrax, lactating patients can pump and discard breast milk during therapy and for 2 days after the last levofloxacin dose, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and the benefits of treatment to the mother.
-Ask your physician before taking any medication during pregnancy or lactation.
Manufacture
SANOFI
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