Panadol Advance 500mg 48 tablets

Nonopioid analgesic used as antipyretic, treatment of mild to moderate pain and peri-/postoperative management of pain.

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally. Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours Usual Adult Paracetamol Dose for Pain: General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally. Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours Usual Pediatric Dose for Fever: Oral or Rectal: <=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed. >1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours) Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.) >=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours. Usual Pediatric Dose for Pain: Oral or Rectal: <=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed. >1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours) Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.) >=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.

Along with its needed effects, acetaminophen (the active ingredient contained in Paracetamol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking acetaminophen: Rare Bloody or black, tarry stools bloody or cloudy urine fever with or without chills (not present before treatment and not caused by the condition being treated) pain in the lower back and/or side (severe and/or sharp) pinpoint red spots on the skin skin rash, hives, or itching sore throat (not present before treatment and not caused by the condition being treated) sores, ulcers, or white spots on the lips or in the mouth sudden decrease in the amount of urine unusual bleeding or bruising unusual tiredness or weakness yellow eyes or skin Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen: Symptoms of overdose Diarrhea increased sweating loss of appetite nausea or vomiting stomach cramps or pain swelling, pain, or tenderness in the upper abdomen or stomach area.

Do not use more of this medication than is recommended. An overdose of paracetamol can cause serious harm. The maximum amount of paracetamol for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more paracetamol could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking paracetamol and never use more than 2 grams (2000 mg) per day. Do not use this medication without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease (cirrhosis). You may not be able to use paracetamol . Before using paracetamol , tell your doctor if you have liver disease or a history of alcoholism.

Store Below 30°C.

Alcohol → increased hepatotoxicity Enzyme inducers (e.g., rifampicin, carbamazepine) → ↑ liver risk Chronic high-dose use with warfarin → ↑ INR

Pregnancy: Considered safe at recommended doses Lactation: Safe; compatible with breastfeeding

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