Norvapril 5/10 mg - 30 Capsules

Angiotensin-converting enzyme inhibitor and calcium channel blocker combination therapy used in the treatment of hypertension.

Administer with or without food.

Side effects due to amlodipine: Peripheral edema, flushing, palpitations, pruritus , skin rash, abdominal pain, nausea, dizziness, drowsiness, fatigue, male sexual disorder, asthenia, muscle cramps, dyspnea, peripheral ischemia, sinus tachycardia, syncope, vasculitis, diaphoresis, erythema multiforme, hot flash, hyperglycemia, weight gain, weight loss, anorexia, constipation, dysphagia, flatulence, gingival hyperplasia, pancreatitis, vomiting, xerostomia, difficulty in micturition, nocturia, urinary frequency, leukopenia, purpuric disease, thrombocytopenia, angioedema, hypersensitivity reaction, abnormal dreams, anxiety, depersonalization, depression, female sexual disorder, hypoesthesia, insomnia, malaise, pain, paresthesia, peripheral neuropathy, rigors, vertigo, arthralgia, back pain, myalgia, osteoarthritis, tremor, conjunctivitis, diplopia, eye pain, tinnitus and epistaxis. Side effects due to Benazepril: Hyperkalemia, cough, angioedema, dizziness, drowsiness, headache, orthostatic dizziness, flushing, hypotension, alopecia, diaphoresis, pemphigus, skin photosensitivity, Stevens-Johnson syndrome, decreased libido, constipation, gastritis, melena, nausea, vomiting, impotence, urinary frequency, urinary tract infection, hemolytic anemia, thrombocytopenia, anxiety, fatigue, hypertonia, insomnia, nervousness, paresthesia, arthralgia, arthritis, asthenia, myalgia, asthma, bronchitis, cough, dyspnea and sinusitis.

-Should not be given to patients suffering from hypersensitivity to amlodipine or benazepril. -The most common side effect of amlodipine is peripheral edema. -May be associated with deterioration of renal function and/or increases in serum creatinine, particularly in patients with low renal blood flow. -Hyperkalemia may occur with ACE inhibitors. -Hypotension can occur with ACE inhibitors (usually with the first several doses). -ACE inhibitors may cause dry cough. -ACE inhibitors may cause cholestatic jaundice. -Use amlodipine with extreme caution in patients with severe aortic stenosis. -Use benazepril with caution in patients with collagen vascular disease. -Use amlodipine with caution in patients with hepatic impairment. -Use amlodipine with caution in patients with hypertrophic cardiomyopathy with left ventricular outflow tract obstruction. -Not recommended in patients with severe renal impairment. -In case of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.

Store at room temperature.

Interactions due to amlodipine: -Alfuzosin: May enhance the hypotensive effect of blood pressure lowering agents. -Antipsychotic Agents: blood pressure lowering agents may enhance the hypotensive effect of antipsychotic agents. -Calcium Salts: May diminish the therapeutic effect of calcium channel blockers. -Carbamazepine: amlodipine may increase the serum concentration of carbamazepine. -Clopidogrel: calcium channel blockers may diminish the therapeutic effect of Clopidogrel. -Dabigatran Etexilate: Amlodipine may diminish the therapeutic effect of Dabigatran Etexilate. -Dantrolene: May enhance the hyperkalemic effect of calcium channel blockers. -Dapoxetine: May enhance the orthostatic hypotensive effect of calcium channel blockers. -Lovastatin: Amlodipine may increase the serum concentration of Lovastatin. -Magnesium Sulfate: May enhance the adverse/toxic effect of calcium channel blockers. -Melatonin: May diminish the antihypertensive effect of calcium channel blockers. -Red Yeast Rice: Amlodipine may increase the serum concentration of Red Yeast Rice. -Simvastatin: Amlodipine may increase the serum concentration of Simvastatin. Interactions due to Benazepril: see pregnancy and lactation.

-Drugs that act directly on the renin-angiotensin system can cause injury to the developing fetus. -Amlodipine and benazepril are present in breast milk. -Ask your physician before taking any medication during pregnancy and lactation. Interactions due to Benazepril: -Allopurinol: Angiotensin-converting enzyme inhibitors may enhance the potential for allergic or hypersensitivity reactions to Allopurinol. -Azathioprine: angiotensin-converting enzyme inhibitors may enhance the myelosuppressive effect of Azathioprine. -Duloxetine: blood pressure lowering agents may enhance the hypotensive effect of duloxetine. -Ferric gluconate: Angiotensin-converting enzyme inhibitors may enhance the adverse/toxic effect of Ferric gluconate. -Ferric hydroxide polymaltose complex: Angiotensin-converting enzyme inhibitors may enhance the adverse/toxic effect of Ferric hydroxide polymaltose complex. -Iron dextran complex: Angiotensin-converting enzyme inhibitors may enhance the adverse/toxic effect of iron dextran complex. -Levodopa-containing products: Blood pressure lowering agents may enhance the hypotensive effect of Levodopa-Containing Products. -Lithium: Angiotensin-converting enzyme inhibitors may increase the serum concentration of Lithium. -Nicorandil: May enhance the hyperkalemic effect of angiotensin-converting enzyme inhibitors. -Nonsteroidal anti-inflammatory agents: Angiotensin-converting enzyme inhibitors may enhance the adverse/toxic effect of nonsteroidal anti-inflammatory agents. -Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of blood pressure lowering agents. -Pregabalin: Angiotensin-converting enzyme inhibitors may enhance the adverse/toxic effect of Pregabalin. -Salicylates: May enhance the nephrotoxic effect of angiotensin-converting enzyme inhibitors. -Tizanidine: May enhance the hypotensive effect of angiotensin-converting enzyme inhibitors. -Trimethoprim: May enhance the hyperkalemic effect of angiotensin-converting enzyme inhibitors.