Loratadine 5 mg/5 ML 60 ML Susp.

Loratadine is a Histamine H1 antagonist; second generation antihistamine and is used to manage symptoms of allergic rhinitis, conjunctivitis, Urticaria and other allergic dermatologic conditions.

-Administer without regard to meals. -Shake well before use.

-Common: Headache , sedated state , drowsiness , fatigue , nervousness, xerostomia ,abdominal pain, vomiting , diarrhea, hyperkinetic muscle activity -Less common:skin rash, gastritis (adults),nausea (adults), hypersensitivity reaction.

-Use with caution for patients with hepatic impairment. -Use with caution for patients with renal impairment. -Incase of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.

Store at room temperature.

-Alcohol (Ethyl): CNS Depressants may enhance the CNS depressant effect of Alcohol (Ethyl). -Amantadine: May enhance the anticholinergic effect of Anticholinergic Agents -Amiodarone: May increase the serum concentration of Loratadine. -Anticholinergic Agents: May enhance the adverse/toxic effect of other Anticholinergic Agents -CloZAPine: Anticholinergic Agents may enhance the constipating effect of CloZAPine. -CNS Depressants: May enhance the adverse/toxic effect of other CNS Depressants. -Gastrointestinal Agents (Prokinetic): Anticholinergic Agents may diminish the therapeutic effect of Gastrointestinal Agents (Prokinetic). -Metoclopramide: May enhance the CNS depressant effect of CNS Depressants. -Nitroglycerin: Anticholinergic Agents may decrease the absorption of Nitroglycerin. -Thiazide and Thiazide-Like Diuretics: Anticholinergic Agents may increase the serum concentration of Thiazide and Thiazide-Like Diuretics. -Topiramate: Anticholinergic Agents may enhance the adverse/toxic effect of Topiramate. -Food increases bioavailability and delays peak.

-Loratadine may be used when a second generation antihistamine is needed. The lowest effective dose should be used -The relative infant dose (RID) of loratadine has been calculated to be 1.1% when compared to a maternal dose of 40 mg/day of loratadine .In general, breastfeeding is considered acceptable when the RID is <10%.

MISR