Co-irbesartan 150/12.5 mg - 14 F.C. Tablet

Angiotensin II receptor blocker and thiazide diuretic combination therapy used in the treatment of hypertension.

Administer with or without food.

-Side effects due to Irbesartan: Hyperkalemia, orthostatic hypotension, diarrhea, dyspepsia, heartburn, dizziness, fatigue, orthostatic dizziness, urticaria, anemia, thrombocytopenia, hepatitis, increased liver enzymes, jaundice, anaphylactic shock, anaphylaxis, angioedema, increased phosphokinase in blood specimen and tinnitus. -Side effects due to hydrochlorothiazide: Skin photosensitivity, hypokalemia, hypomagnesemia, hypercalcemia, and hyponatremia may occur with hydrochlorothiazide, hyperuricemia, myopia and acute angle-closure glaucoma, hypersensitivity angiitis, hypotension (including orthostatic), alopecia, skin rash, toxic epidermal necrolysis, urticaria, glycosuria, hypomagnesemia, abdominal cramps, anorexia, constipation, diarrhea, gastric irritation, nausea, vomiting, aplastic anemia, thrombocytopenia, anaphylaxis, dizziness, headache, paresthesia, restlessness, vertigo, asthenia, muscle spasm, blurred vision, xanthopsia, acute kidney injury and fever.

-Should not be given to patients suffering from Hypersensitivity to Irbesartan or hydrochlorothiazide. -May cause hyperkalemia. -Gout can be precipitated by hydrochlorothiazide. -Symptomatic hypotension may occur upon initiation of therapy in patients who are salt- or volume-depleted. -Hydrochlorothiazide may cause acute transient myopia and acute angle-closure glaucoma. -Hydrochlorothiazide may cause photosensitivity. -May cause deterioration of renal function and/or increases in serum creatinine, particularly in patients with low renal blood flow. -Use with caution in patients with significant aortic/mitral stenosis. -Use hydrochlorothiazide with caution in patients with prediabetes or diabetes mellitus. -Use caution in patients with severe hepatic impairment. -Thiazide diuretics may decrease renal calcium excretion. -Use Irbesartan with caution in patients with unstented unilateral/bilateral renal artery stenosis. -Hydrochlorothiazide can cause SLE exacerbation or activation. -In case of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.

Store at room temperature.

Interactions due to Irbesartan: -Alfuzosin: May enhance the hypotensive effect of blood pressure lowering agents. -Antipsychotic Agents: blood pressure lowering agents may enhance the hypotensive effect of Antipsychotic Agents. -Dapoxetine: May enhance the orthostatic hypotensive effect of Angiotensin II Receptor Blockers. -Duloxetine: blood pressure lowering agents may enhance the hypotensive effect of Duloxetine. -Levodopa-containing products: blood pressure lowering agents may enhance the hypotensive effect of Levodopa-containing products. -Lithium: Angiotensin II Receptor Blockers may increase the serum concentration of Lithium. -Nonsteroidal Anti-Inflammatory Agents: Angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents. -Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of blood pressure lowering agents. -Potassium Salts: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. -Trimethoprim: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Interactions due to hydrochlorothiazide: -Alcohol (Ethyl): May enhance the orthostatic hypotensive effect of Thiazide and Thiazide-Like Diuretics. -Allopurinol: Thiazide Diuretics may enhance the potential for allergic or hypersensitivity reactions to Allopurinol. -Antidiabetic Agents: Thiazide Diuretics may diminish the therapeutic effect of Antidiabetic Agents. -Multivitamins/Minerals (containing vitamins ADEK, Folate, Iron): Thiazide Diuretics may enhance the hypercalcemic effect of Multivitamins/Minerals (containing vitamins ADEK, Folate, Iron). -Nonsteroidal Anti-Inflammatory Agents: Thiazide Diuretics may enhance the nephrotoxic effect of Nonsteroidal Anti-Inflammatory Agents. -Vitamin D Analogs: Thiazide Diuretics may enhance the hypercalcemic effect of Vitamin D Analogs.

-Drugs that act on the renin-angiotensin system can cause injury to the developing fetus. -Thiazide diuretics are found in breast milk; excretion of Irbesartan is not known. Due to the potential for serious adverse reactions in the breastfeeding infant, breastfeeding is not recommended during treatment. -Ask your physician before taking any medication during pregnancy or lactation.

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