Cephlex 250 mg - 12 Capsules

Antibiotic belongs to first generation cephalosporin used in the treatment of Streptococcal pharyngitis, urinary tract infection, skin and soft tissue infection and prosthetic joint infection.

-Administer without regard to food. -Administer with food to decrease the gastrointestinal distress. -Oral suspension: Shake suspension well before use. -Pediatric dosing: -General dosing for the susceptible infections: Infants, children, and adolescents: Mild to moderate infection: Oral: 25 to 50 mg/kg/day divided every 6 to 12 hours; maximum daily dose: 2,000 mg/day. While in case of severe infection: Oral: 75 to 100 mg/kg/day divided every 6 to 8 hours; maximum daily dose: 4,000 mg/day. -Acute otitis media (AOM): Children >1 year and adolescents <15 years: Oral: 75 to 100 mg/kg/day divided every 6 hours. For patients with severe disease or who are <2 years of age, treatment duration is 10 days; while in case of patients ≥2 years of age with mild to moderate disease treatment duration is 5 to 7 days. -Community-acquired pneumonia: Infants >3 months, children, and adolescents: Oral: 75 to 100 mg/kg/day divided every 6 to 8 hours; maximum daily dose: 4,000 mg/day. The usual total duration of therapy for uncomplicated pneumonia is 5 to 10 days. -Streptococcal pharyngitis/tonsillitis: Infants, children, and adolescents: Oral: 40 mg/kg/day divided every 12 hours for 10 days; maximum dose: 500 mg/dose. -Urinary tract infection: Infants, children, and adolescents: In case of mild to moderate infections (eg, cystitis): Oral: 25 to 50 mg/kg/day divided every 6 to 12 hours; maximum dose: 500 mg/dose. While in case of severe infections (eg, pyelonephritis): Oral: 50 to 100 mg/kg/day divided every 6 to 8 hours; maximum dose: 1,000 mg/dose. Duration of therapy: Should be individualized based on patient age, severity/extent of infection, and clinical response; typical duration is 7 to 14 days, though it may be as short as 3 to 5 days (eg, for uncomplicated cystitis in patients ≥2 years of age).

-Clostridioides difficile associated diarrhea, hemolytic anemia and hypersensitivity reactions. -Erythema multiforme, genital pruritus, abdominal pain, diarrhea, dyspepsia, gastritis, nausea, pruritus ani, vomiting, genital candidiasis, vaginal discharge, vaginitis, eosinophilia, neutropenia, thrombocytopenia, cholestatic jaundice, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, agitation, confusion, dizziness, fatigue, hallucination, headache, arthralgia, arthritis, arthropathy and interstitial nephritis.

-Should not be given to patients suffering from hypersensitivity to cephalexin. -May be associated with increased INR, especially in nutritionally-deficient patients. -Use with caution in patients with a history of penicillin allergy. -Use with caution in patients with a history of seizure disorder. -Prolonged use may result in fungal or bacterial superinfection. -Use with caution in patients with renal impairment. -In case of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.

Store at room temperature.

-Aminoglycosides: Cephalosporins may enhance the nephrotoxic effect of Aminoglycosides. -BCG vaccine: Antibiotics may diminish the therapeutic effect of BCG vaccine. -Metformin: Cephalexin may increase the serum concentration of Metformin. -Multivitamins/Minerals (containing vitamins ADEK, Folate, Iron): May decrease the serum concentration of Cephalexin. -Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. -Vitamin K Antagonists (eg, warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists. -Zinc Salts: May decrease the absorption of Cephalexin.

-Cephalexin crosses the placenta. Based on available data, cephalosporin antibiotics, including cephalexin, are generally considered compatible for use during pregnancy. Cephalexin is one of the recommended antibiotics for use prior to vaginal delivery in patients at high risk for endocarditis. -Cephalexin is present in breast milk. The relative infant dose (RID) of cephalexin is 0.13% to 0.52%. In general, breastfeeding is considered acceptable when the relative infant dose is <10%. When an antibiotic is needed, cephalexin may be used to treat mastitis in breastfeeding patients, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother. -Ask the physician before taking any medication during pregnancy or lactation.

KAHIRA