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Cefalotrigenex 200 mg - 8 F.C. Tablet

This page may not cover all the information mentioned in the attached pamphlet of the manufacturing company

Medical Description

Antibiotic, belongs to Cephalosporin group (Third Generation) used in the treatment of acute bacterial rhinosinusitis, gonococcal infection, streptococcal pharyngitis, urinary tract infection and Typhoid fever.

Indication & Usage

-Acute bacterial rhinosinusitis: Oral: 400 mg once daily with clindamycin for 5 to 7 days; some experts use as monotherapy when the risk of drug-resistant streptococcus pneumoniae is low (eg, <65 years of age, low endemic resistance, few comorbidities, no recent hospitalization or antibiotic use). -Streptococcal pharyngitis: Oral: 400 mg once daily for 10 days. -Gonococcal infection: Oral: 800 mg as a single dose; give in combination with treatment for chlamydia if it has not been excluded. -Urinary tract infection: Acute uncomplicated cystitis: Oral: 400 mg once daily for 7 days. While in case of complicated urinary tract infection (including pyelonephritis) : Oral: 400 mg once daily for 10 to 14 days. -Typhoid fever: Oral: 100 to 200 mg twice daily for 7 to 14 days. -Pediatric dosing: -General dosing; susceptible infection (mild to moderate): Infants, children, and adolescents: Oral: 8 mg/kg/day once daily or in divided doses every 12 hours; maximum daily dose: 400 mg/day. -Otitis media, acute: Oral suspension or chewable tablets: Infants, Children, and Adolescents: Oral: 8 mg/kg/day once daily or in divided doses every 12 hours; maximum daily dose: 400 mg/day. -Streptococcus pyogenes pharyngitis or tonsillitis: Infants, children, and adolescents: Oral: 8 mg/kg/day once daily or in divided doses every 12 hours for 10 days; maximum daily dose: 400 mg/day. -Acute bacterial rhinosinusitis: Infants, children, and adolescents: Oral: 8 mg/kg/day once daily or in divided doses every 12 hours with concomitant clindamycin for 10 to 14 days; maximum daily dose: 400 mg/day. -Acute urinary tract infection: Infants ≥2 months, children, and adolescents: Limited data available in infants <6 months: Oral: 8 mg/kg/day once daily or in divided doses every 12 hours for 7 to 14 days.

Active Ingredients

Cefixime

Recommended Doctors

No Recommended Doctors Found

Dosage & Administration

-May be administered with or without food. -Shake oral suspension well before use. -For pediatrics, administer with food to decrease GI distress.

Side Effects

-Diarrhea, abdominal pain, nausea, dyspepsia, flatulence, loose stools, acute renal failure, anaphylactoid reaction, anaphylaxis, angioedema, candidiasis, dizziness, drug fever, eosinophilia, erythema multiforme, facial edema, fever, headache, hepatitis, hyperbilirubinemia, increased blood urea nitrogen, increased serum creatinine, increased serum transaminases, jaundice, leukopenia, neutropenia, prolonged prothrombin time, pruritus, pseudomembranous colitis, seizure, serum sickness-like reaction, skin rash, Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, urticaria, vaginitis, vomiting.

Safety Advice

-In case of renal impairment, if the creatinine clearance is >20 to <60 mL/minute: 300 mg once daily, while if the creatinine clearance is ≤20 mL/minute: 200 mg once daily.(when needed) -Should not be given to the patients suffering from hypersensitivity to cefixime. -Use with caution in patients with a history of gastrointestinal disease. -Should not be given to patients with a history of cephalosporin-associated hemolytic anemia. -Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis. -Incase of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.

Storage

Store at room temperature.

Drug Interactions

-BCG Vaccine: Antibiotics may diminish the therapeutic effect of BCG vaccine. -Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. -Vitamin K Antagonists (eg, warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists. -Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol.

Pregnancy & Lactation

-Cefixime crosses the placenta and can be detected in the amniotic fluid. An increased risk of major birth defects or other adverse fetal or maternal outcomes has generally not been observed following use of cephalosporin antibiotics. -It is not known whether cefixime is present in breast milk, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother.

Manufacture

SHIFA MEDICAL PRODUCTS

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