Medical Description
Antibiotic belongs to first generation cephalosporins used in the treatment of streptococcal pharyngitis, skin and soft tissue infection, prosthetic joint infection and urinary tract infection.
Indication & Usage
-Streptococcal pharyngitis: Oral: 1 g once daily for 10 days.
-Urinary tract infection: Acute uncomplicated or acute simple cystitis (infection limited to the bladder without signs/symptoms of upper tract, prostate, or systemic infection): Oral: 500 mg twice daily for 5 to 7 days. While in case of complicated urinary tract infection (including pyelonephritis): Oral: 1 g twice daily for 10 to 14 days.
-Skin and soft tissue infection: In case of mild and non-purulent cellulitis: Oral: 1 g once daily or 500 mg twice daily for 5 days; duration may be extended up to 14 days if not resolved/slow response. While in case of suppression of recurrent infection cellulitis: Oral: 500 mg twice daily after completion of treatment.
-Prosthetic joint infection: Oral: 500 mg every 12 hours.
-Pediatric dosing:
-General dosing for susceptible infections: Mild to moderate infection: Infants, children, and adolescents: Oral: 15 mg/kg/dose twice daily; maximum daily dose: 2,000 mg/day.
-Pharyngitis/tonsillitis: Children and adolescents: Oral: 30 mg/kg/day in a single dose or divided every 12 hours for 10 days; maximum daily dose: 1,000 mg/day.
-Urinary tract infections: Children and adolescents: Oral: 15 mg/kg/dose every 12 hours; maximum daily dose: 2,000 mg/day.
-Skin and skin structure infections: Children and adolescents: Oral: 15 mg/kg/dose every 12 hours; maximum daily dose: 1,000 mg/day.
Active Ingredients
Cefadroxil
Dosage & Administration
-Administer without regards to meals.
-Administer with food to diminish gastrointestinal complaints.
-Suspension: Shake suspension well before use.
Side Effects
Diarrhea, abdominal pain, agranulocytosis, anaphylaxis, angioedema, arthralgia, cholestasis, Clostridioides difficile-associated diarrhea, dyspepsia, erythema multiforme, erythematous rash, fever, genital candidiasis, hepatic failure, increased serum transaminases, maculopapular rash, nausea, neutropenia, pruritus, pseudomembranous colitis, serum sickness, Stevens-Johnson syndrome, thrombocytopenia, urticaria, vaginitis and vomiting.
Safety Advice
-Should not be given to patients suffering from hypersensitivity to cefadroxil.
-Anaphylaxis may occur.
-Use with caution in patients with a history of penicillin allergy.
-Prolonged use may result in fungal or bacterial superinfection.
-Use with caution in patients with a history of gastrointestinal disease, particularly colitis.
-Use with caution in patients with renal impairment.
-In case of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.
Storage
Store at room temperature.
Drug Interactions
-Aminoglycosides: Cephalosporins may enhance the nephrotoxic effect of Aminoglycosides.
-BCG Vaccine: Antibiotics may diminish the therapeutic effect of BCG Vaccine.
-Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.
-Vitamin K Antagonists (eg, warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists.
Pregnancy & Lactation
-Cefadroxil crosses the placenta, based on the available data, cephalosporin antibiotics are generally considered compatible for use during pregnancy.
-Cefadroxil is present in breast milk. The relative infant dose (RID) of cefadroxil is 2.6%, in general, breastfeeding is considered acceptable when the RID of a medication is <10%. In general, antibiotics that are present in breast milk may cause non-dose-related modification of bowel flora. Monitor infants for GI disturbances.
-Ask your physician before taking any medication during pregnancy or lactation.