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Amoxil 125 mg/5 ML Susp. 100 ML

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Medical Description

Antibiotic; belongs to the penicillin group used in the treatment of acute otitis media, pneumonia, acute bacterial rhinosinusitis, streptococcal pharyngitis, urinary tract infection, Helicobacter pylori eradication and odontogenic infection.

Indication & Usage

-Pediatric dosing: -General dosing for the susceptible infection: In case of mild to moderate infection: Infants ≤3 months: Oral: 25 to 50 mg/kg/day in divided doses every 8 hours, infants >3 months, children, and adolescents: Oral: 25 to 50 mg/kg/day in divided doses every 8 hours; maximum dose: 500 mg/dose. While in case of severe infection (as step-down therapy): Infants, children, and adolescents: Oral: 80 to 100 mg/kg/day in divided doses every 8 hours; maximum dose: 500 mg/dose for most indications. -Acute otitis media: Infants ≥2 months and children: Oral: 80 to 90 mg/kg/day in divided doses every 12 hours; variable duration of therapy, if <2 years of age or severe symptoms (any age): 10-day course; if 2 to 5 years of age with mild to moderate symptoms: 7-day course; ≥6 years of age with mild to moderate symptoms: 5- to 7-day course. -Community-acquired pneumonia: Infants ≥3 months, children, and adolescents: Empiric therapy for presumed bacterial pneumonia: Oral: 90 mg/kg/day in divided doses every 12 hours; maximum daily dose: 4,000 mg/day. -Acute bacterial rhinosinusitis: Low dose: Children ≥2 years and adolescents: Oral: 45 mg/kg/day in divided doses every 12 hours. High dose: Children ≥2 years and adolescents: Oral: 80 to 90 mg/kg/day in divided doses every 12 hours; maximum dose: 2,000 mg/dose. -Streptococcal tonsillopharyngitis: Immediate release (oral suspension, chewable tablets, tablets, capsules): Children and adolescents 3 to 18 years: Oral: 50 mg/kg once daily or 25 mg/kg twice daily for 10 days; maximum daily dose: 1,000 mg/day. Or extended-release tablets: Children ≥12 years and adolescents: Oral: 775 mg once daily for 10 days.

Active Ingredients

Amoxicillin

Recommended Doctors

No Recommended Doctors Found

Dosage & Administration

-Administer around-the-clock to promote less variation in peak and trough serum levels. -Immediate release: May be administered on an empty or full stomach -Extended release: Administer within 1 hour of finishing a meal; do not chew or crush tablet. -Suspension: Shake well before use.

Side Effects

-Antibiotic-associated diarrhea (AAD), nausea, and vomiting, Clostridioides difficile infection (CDI), drug-induced liver injury, urticaria, angioedema and anaphylaxis. -Diarrhea, nausea, vulvovaginal infection, headache, abdominal pain, vomiting, hypersensitivity angiitis, acute generalized exanthematous pustulosis, erythema multiforme, erythematous maculopapular rash, exfoliative dermatitis, skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, crystalluria, agranulocytosis, anemia, eosinophilia, hemolytic anemia, immune thrombocytopenia, leukopenia, neutropenia, thrombocytopenia, cholestatic hepatitis, cholestatic jaundice, hepatitis, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, agitation, anxiety, behavioral changes, confusion, dizziness, hyperactive behavior, insomnia and seizure.

Safety Advice

-Should not be given to patients suffering from hypersensitivity to amoxicillin. -Use is contraindicated in patients with a history of amoxicillin-associated hepatic dysfunction. -A high percentage of patients with infectious mononucleosis develop an erythematous rash during amoxicillin therapy; avoid use in these patients. -Prolonged use may result in fungal or bacterial superinfection. -Use with caution in patients with renal impairment. -Older adults are at increased risk for neurotoxicity (eg, seizures) related to penicillins due to decreased renal clearance. -In case of over dose be ready to tell or show what was taken, how much and when it happened, and seek immediate medical attention. For additional information call us on 16676. Always tell your physician your detailed medical history.

Storage

Store at room temperature.

Drug Interactions

-Allopurinol: May enhance the potential for allergic or hypersensitivity reactions to Amoxicillin. -Aminoglycosides: Penicillins may decrease the serum concentration of Aminoglycosides. -Acemetacin: May increase the serum concentration of Penicillins. -BCG Vaccine: Antibiotics may diminish the therapeutic effect of BCG Vaccine. -Methotrexate: Penicillins may increase the serum concentration of Methotrexate. -Mycophenolate: Penicillins may decrease serum concentrations of the active metabolite(s) of Mycophenolate. -Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. -Tetracyclines: May diminish the therapeutic effect of Penicillins. -Vitamin K Antagonists (eg, warfarin): Penicillins may enhance the anticoagulant effect of Vitamin K Antagonists.

Pregnancy & Lactation

-Amoxicillin crosses the placenta. As a class, penicillin antibiotics are widely used in pregnant patients. Based on available data, penicillin antibiotics are generally considered compatible for use during pregnancy. Amoxicillin is considered compatible for the treatment airway diseases in pregnant patients. -Amoxicillin is present in breast milk, amoxicillin is considered compatible with breastfeeding when used in usual recommended doses. Amoxicillin may be used to treat mastitis in breastfeeding patients. -Ask your physician before taking any medication during pregnancy or lactation.

Manufacture

MUP

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